Endocrine Abstracts

Objectives: Endothelial dysfunction contributes to the development of atherosclerosis in diabetic subjects. Endothelin-1 (ET-1) is an endothelium derived vasoconstrictor. It has been shown that ET-1 levels are increased in a variety of situations such as diabetes, hypertension and obesity. Transforming growth factor beta1 (TGF-β1) is an important cytokine for the development of renal injury in type 2 diabetic patients and associated with hyperglycemia and insulin resistan...